Characteristics of Synthesis of Very‐Long‐Chain Saturated and Tetraenoic Fatty Acids in Swine Cerebral Microsomes
作者： Satoshi Yoshida , Masazumi Takeshita
DOI: 10.1111/J.1471-4159.1986.TB01746.X
关键词:
摘要: : The elongation of arachidoyl-CoA (20:0-CoA) yielded 22:0 and 24:0 concomitantly, whereas the behenoyl-CoA (22:0-CoA) only a negligible amount in adult swine cerebral microsomes. dependence on time, pH, substrate concentrations were examined for synthesis from 20:0-CoA. A microcomputer-aided simulation study suggested that there two parallel pathways 20:0-CoA to 24:0. 22:0-CoA could not be observed microsomes; however, it was clearly newborn rat brain dilution experiment with addition cold reaction confirmed above suggestion no intermediate appeared during endogenous 20:4-CoA 22:4 24:4 microsomes, presence similar those involved suggested.
sci-hub.se 参考文章(16)
Jean-Marie Bourre, Odile Daudu, Nicole Baumann, Nervonic acid biosynthesis by erucyl-coa elongation in normal and quaking mouse brain microsomes. Elongation of other unsaturated fatty acyl-CoAs (mono and polyunsaturated) Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. ,vol. 424, pp. 1- 7 ,(1976) , 10.1016/0005-2760(76)90043-6
John T. Bernert, Jean-Marie Bourre, Nicole A. Baumann, Howard Sprecher, The activity of partial reactions in the chain elongation of palmitoyl-CoA and stearoyl-CoA by mouse brain microsomes. Journal of Neurochemistry. ,vol. 32, pp. 85- 90 ,(1979) , 10.1111/J.1471-4159.1979.TB04513.X
Satoshi Yoshida, Masazumi Takeshita, Akihiko Kawaguchi, Stereospecific incorporation of hydrogens from NADPH in elongation of very long fatty acyl-CoA by swine cerebral microsomes. Biochemical and Biophysical Research Communications. ,vol. 124, pp. 322- 328 ,(1984) , 10.1016/0006-291X(84)91556-0
J-. M. Bourre, G. Pascal, G. Durand, M. Masson, O. Dumont, M. Piciotti, Alterations in the Fatty Acid Composition of Rat Brain Cells (Neurons, Astrocytes, and Oligodendrocytes) and of Subcellular Fractions (Myelin and Synaptosomes) Induced by a Diet Devoid of n-3 Fatty Acids Journal of Neurochemistry. ,vol. 43, pp. 342- 348 ,(1984) , 10.1111/J.1471-4159.1984.TB00906.X
I. Goldberg, I. Shechter, K. Bloch, Fatty Acyl-Coenzyme A Elongation in Brain of Normal and Quaking Mice Science. ,vol. 182, pp. 497- 499 ,(1973) , 10.1126/SCIENCE.182.4111.497
John Dobbing, Jean Sands, Comparative aspects of the brain growth spurt Early Human Development. ,vol. 3, pp. 79- 83 ,(1979) , 10.1016/0378-3782(79)90022-7
T.Sanjeeva Reddy, Nicolas G. Bazan, Kinetic properties of arachidonoyl-coenzyme A synthetase in rat brain microsomes Archives of Biochemistry and Biophysics. ,vol. 226, pp. 125- 133 ,(1983) , 10.1016/0003-9861(83)90277-1
Harold W. Cook, Chain elongation in the formation of polyunsaturated fatty acids by brain: Some properties of the microsomal system Archives of Biochemistry and Biophysics. ,vol. 214, pp. 695- 704 ,(1982) , 10.1016/0003-9861(82)90076-5
J. M. Bourre, S. Pollet, M. Paturneau-Jouas, N. Baumann, Fatty Acid Biosynthesis during Brain Development Advances in Experimental Medicine and Biology. ,vol. 101, pp. 17- 26 ,(1978) , 10.1007/978-1-4615-9071-2_2
M T Clandinin, K Wong, R R Hacker, Synthesis of chain elongation-desaturation products of linoleic acid by liver and brain microsomes during development of the pig. Biochemical Journal. ,vol. 226, pp. 305- 309 ,(1985) , 10.1042/BJ2260305