Malaria transmission blocking immunity and sexual stage vaccines for interrupting malaria transmission in Latin America.

摘要: Malaria is a vector-borne disease that considered to be one of the most serious public health problems due its high global mortality and morbidity rates. Although multiple strategies for controlling malaria have been used, many had limited impact appearance rapid dissemination mosquito resistance insecticides, parasite antimalarial drug, lack sustainability. Individuals in endemic areas permanently exposed develop specific immune responses capable diminishing burden clinical manifestations disease, including blocking transmission vector. This referred as (TB) immunity (TBI) mediated by antibodies other factors ingested during blood meal inhibit development mosquito. These recognize proteins expressed on either gametocytes or stages midgut are potential vaccine candidates. these candidates, collectively called TB vaccines (TBV), would not directly stop from infecting individuals, but infected person non-infected person. Here, we review progress has achieved TBI studies TBV highlight their usefulness low endemicity such Latin America.