Quinazolinone and benzoxazine derivatives as progesterone receptor modulators

摘要: This invention provides compounds which are agonists and antagonists of the progesterone receptor having general structure: wherein: R1 R2 independently selected from H, CORA, or NRBCORA, optionally substituted alkyl, alkenyl, alknyl, cycloalklyl, aryl, heterocyclic moieties; fused to form: 3 8 membered spirocyclic alkenyl rings; RA is H alkoxy, aminoalkyl groups; RB C1 C3 alkyl; R3 OH, NH2, CORC alkynyl; RC aminoalkyl; R4 halogen, CN, NO2, alkynyl, amino R5 an benzene five six ring with 1, 2, heteroatoms O, S, SO, SO2 NR6; R6 G1 NR7, CR7R8; G2 CO, CS, provided that when CR7R8, cannot both be R7 R8 moiety; pharmaceutically acceptable salt thereof, methods using these in mammals as receptor.