miR-338-5p inhibits cell proliferation, colony formation, migration and cisplatin resistance in esophageal squamous cancer cells by targeting FERMT2.

摘要: Esophageal cancer is one of the leading causes death in male population Eastern Asia. In addition, esophageal squamous cell carcinoma (ESCC) major type among world. Owing to poor overall 5-year survival rate, novel effective treatment strategies are needed. MicroRNAs important gene regulators that dysregulated many types. our previous study, we applied next-generation sequencing demonstrate miR-338-5p was downregulated tumor tissue patients with versus without recurrence. this further studied roles ESCC. The expression endogenous at lower levels ESCC cells compared normal cells. Functional assays showed reduced proliferation, colony formation, migration and cisplatin resistance an line, CE-81T. Potential target genes were identified by microarray prediction tools, 31 selected. Among these, Fermitin family homolog 2 (FERMT2) plays oncogenic role ESCC, so it chosen for study. Luciferase direct binding between 3' untranslated region FERMT2. Silencing FERMT2 inhibited resistance. Pathway analysis revealed integrin-linked protein kinase signaling pathway, which participates, significantly affected a mimic. Our results suggest may play antioncogenic via repressing