DRUG-RESISTANT TUBERCULOSIS: RECENT APPROACH IN POLYMER BASED NANOMEDICINE

摘要: Tuberculosis (TB) had been a leading chronic bacterial infection since decades. Current therapeutic management of Mycobacterium tuberculosis (MTB) is inadequate due to the lengthy course treatment, drug-related side effects and ill-planned therapy, these factors can lead failure emergence drug-resistant TB. The Multi-drug-resistant (MDR) TB needs treatment with second-line antitubercular drugs (ATDs) having higher cost. misuse ATDs may result in extremely (XDR) strain which very difficult treat require high doses resulting more toxicity effects. This review highlights need for novel drug delivery drug-susceptible resistant characteristics nanoparticulate system its approach MDR XDR are discussed. lung site pulmonary targeted helps achieving increased efficacy less dose further reducing toxicity. symbiotic association nanotechnology give rise an efficient inhalable polymer based containing better Various loaded nanocarrier systems like Alginate, PLGA, Chitosan Gelatin nanocarriers discussed detail. Thus, this current research nanomedicine their importance control