作者: Tsutomu Ishihara , Yutaka Mizushima
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摘要: Drug-containing nanoparticles are provided that enable effective targeting and sustained-release of a water-soluble, non-peptide, low-molecular weight drug cause reduced accumulation the in liver. The containing obtained by hydrophobicizing metal ion, reacting hydrophobicized with poly(lactic acid)-polyethylene glycol block copolymer or poly(lactic-co-glycolic copolymer. have favorable properties