Granulocyte Colony-Stimulating Factor Enhances the Phagocytic and Bactericidal Activity of Normal and Defective Human Neutrophils

摘要: Granulocyte colony-stimulating factor (G-CSF) stimulates proliferation of myeloid cells and may be a valuable adjunct in prevention treatment neutropenia-associated infections. Neutrophil (PMNL) phagocytic microbicidal functions against Staphylococcus aureus Candida albicans blastoconidia were therefore evaluated. Bacterial phagocytosis bactericidal activity significantly enhanced by approximately 50%-70% after preincubation normal PMNL with G-CSF concentrations 1000-4000 units/ml for 10 min at 37 degrees C. similar the defective from HIV-1-infected patients 70%-150% reached baseline control killing. However, neither nor fungicidal blastoconidia. These data demonstrate that enhances antibacterial but not antifungal activities human vitro also improves patients.