Erythrocyte Membrane Bound ATPase and Antioxidant Enzyme Changes Associated with Vascular Calcification is Reduced by Sodium Thiosulfate

摘要: Sodium thiosulfate (STS), a cyanide antidote has been reported to possess antioxidant and calcium chelation effects, useful for the treatment of renal failure due vascular calcification urolithiasis. The present study investigated in vivo modulatory effects STS on erythrocyte calcium, phosphorous levels, lipid peroxidation, enzyme membrane ATPase activities (Ca2+, Na+K+, Mg2+ 5′′ nucleotidase) an adenine induced model rats. Adenine (0.75%) was supplemented through diet 28 days, which resulted significantly (P < 0.05) increased circulating product oxidative stress within RBCs, as measured from peroxidation reduced enzymes. were altered (increased Ca2+, Na+K+ decreased Mg+ ATPase, 5′ compared rats fed normal diet. (400 mg/kg) given orally effective establishing normalcy RBC alterations. This effect more pronounced, when day 49 after induction calcification, instead 0 28. These findings may benefit evaluate effectiveness therapy patients with chronic associated that leads stiffening smooth muscles aorta, deposition.