FDG-PET imaging in lung cancer: how sensitive is it for bronchioloalveolar carcinoma?

作者: Cecelia Yap , Christiaan Schiepers , Michael Fishbein , Michael Phelps , Johannes Czernin

DOI: 10.1007/S00259-002-0853-Y

关键词:

摘要: While characterization of lung lesions and staging cancer with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is an established clinical procedure, a lower diagnostic accuracy FDG-PET for diagnosis so-called bronchioloalveolar carcinoma (BAC) has been reported. Therefore, the PET diagnosing BAC was investigated. We studied 41 patients eventually found to have adenocarcinoma growth pattern who were referred or whole-body between January 1998 March 2001: there 11 males (27%) 30 females (73%), mean age 66.0±10.9 (range =44–84 years). Patients imaged using ECAT EXACT HR+ systems. All had non-attenuation-corrected scans, while transmission data attenuation correction also available 12 (29%). correctly identified in 46 (89%) 39 (95%). By pathology, 25 (61%) unifocal nodular lesions; this by 20 (80%) CT 18 (72%). 7 (44%) 16 (39%) multicentric diffuse BAC, (69%). Of 35 whose lymph node status verified pathologically, correct 27 (77%) 24 missed 67% rare tumors that pure no invasive component. It concluded performance similar most other non-small cell types. less accurate

参考文章(32)
Liebow Aa, Bronchiolo-alveolar carcinoma. Advances in internal medicine. ,vol. 10, pp. 329- 358 ,(1960)
LH Sobin, WD Travis, TV Colby, B Corrin, Y Shimosato, E Brambilla, Histological Typing of Lung and Pleural Tumours ,(1999)
Kevin L. Berger, Siobhan A. Nicholson, Farrokh Dehdashti, Barry A. Siegel, FDG PET evaluation of mucinous neoplasms: correlation of FDG uptake with histopathologic features. American Journal of Roentgenology. ,vol. 174, pp. 1005- 1008 ,(2000) , 10.2214/AJR.174.4.1741005
M.E. Phelps, E.J. Hoffman, M. Dahlbom, C.K. Hoh, G. Rosenqvist, R.A. Hawkins, C. Schiepers, Whole-body positron emission tomography: Part I. Methods and performance characteristics. The Journal of Nuclear Medicine. ,vol. 33, pp. 1191- 1199 ,(1992)
Hisao Tonami, Yoshihiro Nambu, Kotaro Higashi, Manabu Oguchi, Yoshimichi Ueda, Itaru Yamamoto, Hiroyasu Seki, Kokichi Yuasa, Tetsuro Okimura, Takahiro Nishikawa, Comparison of fluorine-18-FDG PET and thallium-201 SPECT in evaluation of lung cancer The Journal of Nuclear Medicine. ,vol. 39, pp. 9- 15 ,(1998)
Jun Hatazawa, Tatsuo Ido, Kazuo Kubota, Taiju Matsuzawa, Kiichi Ishiwata, Takehiko Fujiwara, Masatoshi Ito, Ren Iwata, Differential diagnosis of lung tumor with positron emission tomography: a prospective study. The Journal of Nuclear Medicine. ,vol. 31, pp. 1927- 1932 ,(1990)
J F Vansteenkiste, S G Stroobants, P R De Leyn, P J Dupont, J Bogaert, A Maes, G J Deneffe, K L Nackaerts, J A Verschakelen, T E Lerut, L A Mortelmans, M G Demedts, Lymph node staging in non-small-cell lung cancer with FDG-PET scan: a prospective study on 690 lymph node stations from 68 patients. Journal of Clinical Oncology. ,vol. 16, pp. 2142- 2149 ,(1998) , 10.1200/JCO.1998.16.6.2142
C A Hill, Bronchioloalveolar carcinoma: a review. Radiology. ,vol. 150, pp. 15- 20 ,(1984) , 10.1148/RADIOLOGY.150.1.6316417
S R Meikle, B F Hutton, D L Bailey, P K Hooper, M J Fulham, Accelerated EM reconstruction in total-body PET: potential for improving tumour detectability Physics in Medicine and Biology. ,vol. 39, pp. 1689- 1704 ,(1994) , 10.1088/0031-9155/39/10/012
Mark H. Whiteford, Heather M. Whiteford, Laurence F. Yee, Olagunju A. Ogunbiyi, Farrokh Dehdashti, Barry A. Siegel, Elisa H. Birnbaum, James W. Fleshman, Ira J. Kodner, Thomas E. Read, Usefulness of FDG-PET scan in the assessment of suspected metastatic or recurrent adenocarcinoma of the colon and rectum Diseases of The Colon & Rectum. ,vol. 43, pp. 759- 767 ,(2000) , 10.1007/BF02238010