Failure of ACAT inhibition to retard atherosclerosis.
作者： Sergio Fazio , MacRae Linton
DOI: 10.1056/NEJME068012
关键词:
摘要: Medical management of atherosclerosis is based on the control its risk factors (dyslipidemia, hypertension, family history, and smoking) predisposing conditions (e.g., metabolic syndrome...
elsevier.com
sci-hub.se 参考文章(14)
M.S. Brown, Y.K. Ho, J.L. Goldstein, The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. Journal of Biological Chemistry. ,vol. 255, pp. 9344- 9352 ,(1980) , 10.1016/S0021-9258(19)70568-7
Carlos Leon, John S. Hill, Kishor M. Wasan, Potential Role of Acyl-Coenzyme A:Cholesterol Transferase (ACAT) Inhibitors as Hypolipidemic and Antiatherosclerosis Drugs Pharmaceutical Research. ,vol. 22, pp. 1578- 1588 ,(2005) , 10.1007/S11095-005-6306-0
Aykut Bilge, Concepcion V. Warner, Oliver W. Press, Translocation of ricin A-chain into proteoliposomes reconstituted from Golgi and endoplasmic reticulum. Journal of Biological Chemistry. ,vol. 270, pp. 23720- 23725 ,(1995) , 10.1074/JBC.270.40.23720
H.Bryan Brewer, Focus on high-density lipoproteins in reducing cardiovascular risk American Heart Journal. ,vol. 148, pp. S14- S18 ,(2004) , 10.1016/J.AHJ.2004.04.027
Yan Ru Su, Dwayne E. Dove, Amy S. Major, Alyssa H. Hasty, Branden Boone, MacRae F. Linton, Sergio Fazio, Reduced ABCA1-Mediated Cholesterol Efflux and Accelerated Atherosclerosis in Apolipoprotein E–Deficient Mice Lacking Macrophage-Derived ACAT1 Circulation. ,vol. 111, pp. 2373- 2381 ,(2005) , 10.1161/01.CIR.0000164236.19860.13
Sergio Fazio, Amy S. Major, Larry L. Swift, Linda A. Gleaves, Michel Accad, MacRae F. Linton, Robert V. Farese, Increased atherosclerosis in LDL receptor–null mice lacking ACAT1 in macrophages Journal of Clinical Investigation. ,vol. 107, pp. 163- 171 ,(2001) , 10.1172/JCI10310
Thomas M.A. Bocan, Sandra Bak Mueller, Paul D. Uhlendorf, Edie Quenby Brown, Michelle J. Mazur, Ann E. Black, Inhibition of acyl-CoA cholesterol O-acyltransferase reduces the cholesteryl ester enrichment of atherosclerotic lesions in the Yucatan micropig Atherosclerosis. ,vol. 99, pp. 175- 186 ,(1993) , 10.1016/0021-9150(93)90020-U
Lawrence L. Rudel, Richard G. Lee, Paolo Parini, ACAT2 Is a Target for Treatment of Coronary Heart Disease Associated With Hypercholesterolemia Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 25, pp. 1112- 1118 ,(2005) , 10.1161/01.ATV.0000166548.65753.1E
Stéphane Perrey, Christiane Legendre, Akihiro Matsuura, Christian Guffroy, Jean Binet, Shigeo Ohbayashi, Toshiya Tanaka, Jean Claude Ortuno, Takeo Matsukura, Thierry Laugel, Paul Padovani, François Bellamy, Alan D Edgar, Preferential pharmacological inhibition of macrophage ACAT increases plaque formation in mouse and rabbit models of atherogenesis Atherosclerosis. ,vol. 155, pp. 359- 370 ,(2001) , 10.1016/S0021-9150(00)00599-2
Kimberly F Buhman, Michel Accad, Robert V Farese Jr, Mammalian acyl-CoA:cholesterol acyltransferases. Biochimica et Biophysica Acta. ,vol. 1529, pp. 142- 154 ,(2000) , 10.1016/S1388-1981(00)00144-X