Long-term electromagnetic field treatment enhances brain mitochondrial function of both Alzheimer's transgenic mice and normal mice: a mechanism for electromagnetic field-induced cognitive benefit?

摘要: We have recently reported that long-term exposure to high frequency electromagnetic field (EMF) treatment not only prevents or reverses cognitive impairment in Alzheimer's transgenic (Tg) mice, but also improves memory normal mice. To elucidate the possible mechanism(s) for these EMF-induced benefits, brain mitochondrial function was evaluated aged Tg mice and non-transgenic (NT) littermates following 1 month of daily EMF exposure. In enhanced by 50-150% across six established measures, being greatest cognitively-important areas (e.g. cerebral cortex hippocampus). increased although enhancement as robust less widespread compared The accompanied 5-10 fold increases soluble Aβ1-40 within same preparations. These amyloid-β peptide (Aβ) were apparently due ability disaggregate Aβ oligomers, which are believed be form causative dysfunction disease (AD). Finally, both occurred through non-thermal effects because temperatures either stable decreased during/after treatment. results collectively suggest may a primary mechanism provides benefit NT Especially context is an early prominent characteristic pathogenesis, could profound value disease's prevention intervention at level.