Seizures during the management of high-grade gliomas: clinical relevance to disease progression.

摘要: This study was performed to evaluate the incidence of seizures with its implications on disease progression and diagnostic value post-ictal magnetic resonance images (MRI) during management high-grade gliomas (HGGs). A total 406 consecutive patients newly diagnosed HGGs were retrospectively reviewed. The investigated. In who experienced a seizure, causality between assessed by pre-ictal, (<1 month), follow-up (<3 months) MRI. After median 17.4 months (range 0.1-88.3), developed in 127 (31 %). Of patients, radiological at MRI found 83 (65 %) confirmed 79 (62 Four other (3 shown be progression-free. Among those without MRI, progression-free 31 (24 %); however, 13 (10 revealed eventual progression. absence preoperative (p = 0.003), <95 % tumor resection 0.001), pre-ictal Karnofsky Performance Scale score ≤ 70 0.025) significantly associated During HGG, seizures; these 72 harbored progressive disease. is useful for detecting progression; there are pitfalls. Clinical settings should considered together diagnosing seizures.