Deficiency of very large G-protein-coupled receptor-1 is a risk factor of tumor-related epilepsy: a whole transcriptome sequencing analysis.

摘要: The majority of patients with low-grade glioma (LGG) experience epileptic seizures as their initial symptom, while the underlying mechanisms tumor-related are still far from being fully understood. In addition to tumor type and location, genetic changes LGGs considered be influential factors in causing seizures. Nevertheless, molecular biomarkers associated epilepsy have rarely been identified. RNA sequence data 80 histologically confirmed LGG were collected Chinese genome atlas database significant differences expression levels 33 genes found. One genes, Very large G-protein-coupled receptor-1 (VLGR1), had previously Therefore, we investigated association between LGG-related VLGR1, which played a role idiopathic epilepsy. level VLGR1 was compared those without using reads per kilobase transcriptome million method. To evaluate prognostic gene expression, progression-free survival determined by Kaplan–Meier method multivariate Cox model. We demonstrated that significantly lower seizure-free (p = 0.003). Furthermore, highly presence statistical However, could not serve an independent factor determine patients. Based on analysis, our results suggest low is risk LGG.