Gangliosides attenuate stress-induced changes on body weight, motor activity and on the behavioral response to 5-methoxy-N,N-dimethyltryptamine.

摘要: Abstract The major goal of this study was to evaluate the influence gangliosides (GANG) treatment on onset adaptive changes and sequelae induced by stress exposure. With purpose, behavioral response 5-metoxy- N,N -dimethyltryptamine (5-MeODMT, 5 mg/kg, IP) motor activity were evaluated in rats previously submitted either a single restraint session (2 h) or daily event for 3 consecutive days, combined not GANG administration (30 mg/kg IP). always injected 2 h before In addition, differences body weights recorded throughout experiments. A similar after 5-MeODMT observed between saline (SAL) unstressed rats. Exposure one three sessions did modify 5-MeODMT, whereas association during days enhanced forepaw treading hindlimb abduction. SAL-treated animals stressful stimuli showed reduced locomotion rearing. combination but unique association, reversed decrease aversive experience. produced recovered only treated with days. These findings suggest that may accelerate 5-HT 1 sites attenuate certain previous