Mild cognitive impairment in Parkinson's disease.

摘要: While Parkinson’s disease (PD) traditionally has been defined by its characteristic motor hallmarks, non-motor features such as cognitive impairment and dementia are increasingly recognized part of PD. Mild is common in non-demented PD patients, occurring about 20-50%. Frequency estimates clinical mild (PD-MCI), however, vary across studies due to methodological differences lack uniform diagnostic criteria for PD-MCI. Overall, PD-MCI patients exhibit nonamnestic deficits domains executive function, attention, visuospatial function; the phenotype heterogeneous with some demonstrating greater amnestic deficits. particularly those posterior cortical profiles, may be at high risk developing dementia. Various biomarkers studied including cerebrospinal fluid, genetic analyses, neuroimaging suggest that there distinct profiles. Future using incorporating longitudinal follow-up cohorts needed understand a transitional state between normal cognition