Cognitive and neurophysiological markers of ADHD persistence and remission.

摘要: Background Attention-deficit hyperactivity disorder (ADHD) persists in around two-thirds of individuals adolescence and early adulthood. Aims To examine the cognitive neurophysiological processes underlying persistence or remission ADHD. Method Follow-up data were obtained from 110 young people with childhood ADHD 169 controls on cognitive, electroencephalogram frequency, event-related potential (ERP) actigraph movement measures after 6 years. Results ADHD persisters differed remitters preparation-vigilance (contingent negative variation, delta activity, reaction time variability omission errors), IQ count, but not executive control inhibition working memory (nogo-P3 amplitudes, commission errors digit span backwards). Conclusions Preparation-vigilance markers remission, improving concurrently symptoms, whereas sensitive to persistence/remission. For IQ, present previous results combined suggest a role moderating outcome. These findings fit previously identified aetiological separation impairments ADHD. The strongest candidates for development non-pharmacological interventions involving training neurofeedback are that remission.