The hemifusion intermediate and its conversion to complete fusion: regulation by membrane composition.
作者： L. Chernomordik , A. Chanturiya , J. Green , J. Zimmerberg
DOI: 10.1016/S0006-3495(95)79966-0
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摘要: To fuse, membranes must bend. The energy of each lipid monolayer with respect to bending is minimized at the spontaneous curvature monolayer. Two lipids known promote opposite curvatures, lysophosphatidylcholine and arachidonic acid, were added different sides planar phospholipid membranes. Lysophosphatidylcholine contacting monolayers fusing inhibited hemifusion we observed between vesicles In contrast, fusion pore formation depended upon distal membrane; promoted acid inhibited. Thus, intermediates pores in involve membrane may have net Biological proceed through similar intermediates.
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