The impact of hyperglycemia on the corneal epithelium: Molecular mechanisms and insight

摘要: Type 2 Diabetes Mellitus (T2DM) is reaching epidemic levels worldwide and with it, there a significant increase in complications associated the disease. T2DM affects virtually all organ systems including eye. While frequently overlooked, diabetic keratopathy most common ocular complication of diabetes can manifest mild to severe forms, latter which poses major threat vision. As initial barrier between environment eye, corneal epithelium functions innate immune defense. Compromise this may predispose cornea infection hinder refractive capabilities The clinical burden patients lies primarily inability repair damage maintain its tight function. Current therapies for are supportive, centering on prevention promotion an optimal healing environment. With no clear disease-modifying agent identified as yet, thorough understanding pathophysiology that underlies development at cellular level critical identify develop potential therapeutic agents capable promoting re-epithelialization accelerate wound process. focus review examine what known regarding molecular mechanisms needed epithelial homeostasis how it goes awry diabetes.