Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in intrahepatic cholangiocarcinoma.
作者： T. TERADA , Y. NAKANUMA
DOI: 10.1111/J.1365-2559.1994.TB01570.X
关键词:
摘要: Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development in cholangiocarcinoma was examined by immunohistochemistry. In the developing hilar ducts, tenascin expressed mesenchyme around epithelial cells migrating from ductal plate into at 10-14 weeks gestation. Tenascin also newly formed ducts 15-20 gestation, but its expression disappeared after 21 Type were plate, mesenchyme, their present throughout fetal life. By contrast, peripheral not found. identified ducts. cholangiocarcinoma, stroma, identified. These findings suggest that may play a role both development. stroma be result malignant transformation biliary epithelium; peritumoral stimulate carcinoma cell proliferation growth cholangiocarcinoma.
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