Nitroxoline inhibits bladder cancer progression by reversing EMT process and enhancing anti-tumor immunity.
作者： Naijin Xu , Wenfeng Lin , Jingkai Sun , Takuya Sadahira , Abai Xu
DOI: 10.7150/JCA.47025
关键词:
摘要: Nitroxoline is considered to be an effective treatment for the urinary tract infections. Recently, it has been found against several cancers. However, few studies have examined anti-tumor activity of nitroxoline in bladder cancer. The purpose study was reveal possible mechanisms how inhibited cancer progression. In vitro assay, we demonstrated that cell growth and migration a concentration-related manner. Western blot analysis downregulated expressions epithelial mesenchymal transition (EMT)-related proteins. Furthermore, with C3H/He mice subcutaneous model resulted significant inhibition tumor growth. Moreover, percentage myeloid-derived suppressor cells (MDSC) peripheral blood significantly decreased after nitroxoline. Taken together, our results suggested may used as potential drug
okayama-u.ac.jp
elsevier.com
sci-hub.st 参考文章(21)
Bojana Mirković, Boštjan Markelc, Miha Butinar, Ana Mitrović, Izidor Sosič, Stanislav Gobec, Olga Vasiljeva, Boris Turk, Maja Čemažar, Gregor Serša, Janko Kos, Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity. Oncotarget. ,vol. 6, pp. 19027- 19042 ,(2015) , 10.18632/ONCOTARGET.3699
Gabriel Nuñez, Mary A Benedict, Yuanmimg Hu, Naohiro Inohara, Caspases: the proteases of the apoptotic pathway Oncogene. ,vol. 17, pp. 3237- 3245 ,(1998) , 10.1038/SJ.ONC.1202581
Virapong Prachayasittikul, Waraporn Chan-On, Huyen Nguyen Thi Bich, Napat Songtawee, Wilasinee Suwanjang, Supaluk Prachayasittikul, Quinoline-based clioquinol and nitroxoline exhibit anticancer activity inducing FoxM1 inhibition in cholangiocarcinoma cells. Drug Design Development and Therapy. ,vol. 9, pp. 2033- 2047 ,(2015) , 10.2147/DDDT.S79313
Bojana Mirković, Miha Renko, Samo Turk, Izidor Sosič, Zala Jevnikar, Nataša Obermajer, Dušan Turk, Stanislav Gobec, Janko Kos, Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds ChemMedChem. ,vol. 6, pp. 1351- 1356 ,(2011) , 10.1002/CMDC.201100098
Janko Kos, Ana Mitrović, Bojana Mirković, The current stage of cathepsin B inhibitors as potential anticancer agents Future Medicinal Chemistry. ,vol. 6, pp. 1355- 1371 ,(2014) , 10.4155/FMC.14.73
Hongchao Jiang, Jori E. Taggart, Xiaoxi Zhang, Doris M. Benbrook, Stuart E. Lind, Wei-Qun Ding, Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline) Cancer Letters. ,vol. 312, pp. 11- 17 ,(2011) , 10.1016/J.CANLET.2011.06.032
Yong Liang, Xinliang Mao, Haiyan Liu, Proteasome inhibitor clioquinol as a candidate drug in prophylaxis and treatment of acute graft-versus-host disease Medical Hypotheses. ,vol. 76, pp. 400- 402 ,(2011) , 10.1016/J.MEHY.2010.11.002
Jean Paul Thiery, Epithelial–mesenchymal transitions in tumour progression Nature Reviews Cancer. ,vol. 2, pp. 442- 454 ,(2002) , 10.1038/NRC822
C. Pelletier, P. Prognon, P. Bourlioux, Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains. Antimicrobial Agents and Chemotherapy. ,vol. 39, pp. 707- 713 ,(1995) , 10.1128/AAC.39.3.707
S Conus, H Simon, Cathepsins and their involvement in immune responses Swiss Medical Weekly. ,vol. 140, ,(2010) , 10.4414/SMW.2010.13042