Characteristics, Mechanisms of Action, and Epitope Mapping of Anti-factor VIII Antibodies
作者： Géraldine Lavigne-Lissalde , Chantal Rothschild , Claire Pouplard , Priscilla Lapalud , Yves Gruel
DOI: 10.1007/S12016-009-8119-0
关键词:
摘要: The development of anti-factor VIII (FVIII) antibodies (Abs), also called inhibitors, is currently one the most serious complications arising during treatment hemophilia A patients. Improved prevention and eradication these Abs remain a challenge both for clinicians scientists. Numerous studies in literature have reported on their epitope specificity, mechanism FVIII inactivation, as well methods used detection. In this review, we summarize current knowledge nature (isotypes, kinetic properties), properties, mechanisms action anti-FVIII Abs. Furthermore, present detection characterization with emphasis Luminex technique susceptible to facilitate monitoring changes specificity
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