Quantification of antiretroviral drugs for HIV-1 in the male genital tract: current data, limitations and implications for laboratory analysis.

摘要: Antiretroviral therapy has reduced the morbidity and mortality associated with HIV-1/AIDS in developed countries. Viral replication blood plasma is suppressed by antiretroviral drugs, whereas virus male genital tract genetically phenotypically unique may not be suppressed. This viral compartmentalization affects drug penetration of capacity for to reduce sexual transmission. The problem having two distinct populations within any given individual compounded fact that drugs penetrate semen varying degrees. Incomplete suppression yield drug-resistant increase risk review critically appraises current studies quantification suggests recommendations address observed limitations.