Topographical Comparison of Lesions in Trisomy 21 and Alzheimer’s Disease: A Study with PET, Anatomical and Neuropathological Investigations

摘要: Recent evidence suggests that Alzheimer’s disease (AD) is a clinically heterogeneous disorder and specific subgroups exist. A human model of AD exists avoids such problems as heterogeneity. Down’s syndrome (DS), trisomy 21, genetic in which an extra portion chromosome 21 leads to mental retardation, short stature, phenotypic abnormalities. DS subjects over 35 years age demonstrate neuropathological neurochemical defects postmortem are virtually indistinguishable from those found brain patients, well universal cognitive deterioration 20%–30% prevalence dementia. In older positron emission tomography (PET) shows identical patterns abnormal glucose metabolism, selectively involving association areas frontal, parietal temporal neocortices, but sparing primary sensory motor regions. demented furthermore, quantitative computer assisted (CT) indicates accelerated neuronal loss atrophy.