Clinical study of Cervagem (ONO-8O2) for application in first and second trimester abortions in Japan

摘要: Prostaglandins (PGs) are routinely used for induction and augmentation of labour, since they have a strong contractile effect on the pregnant uterus. Differing from oxytocin, PGs stimulate uterus not only in third trimester pregnancy but also first second trimesters. Based this, clinical application therapeutic abortion was developed effectiveness PGF2α administered by various routes is widely recognized. However, primary produce side-effects their duration action short. In order to overcome these disadvantages, efficacy synthetic analogues been studied several investigators 1–7. Among them, 16,16-dimethyl-trans-Δ2 PGE1 methyl ester (Cervagem, ONO-8O2), analogue, which induces uterine contractions rats with potency 100 times higher than that PGF2α), found effective termination early intra-uterine instillation 8–9. efforts directed towards development simpler more acceptable administration. 1977 Karim et al.10 showed vaginal administration ONO-802 terminating very 46 out 50 patients minimal side-effects. The findings subsequently confirmed other investigators11–13 two trimesters pregnancy.