Predictors of folate status among pregnant Japanese women: the Hokkaido Study on Environment and Children’s Health, 2002–2012

摘要: The International Clearinghouse for Birth Defects, Surveillance and Research reports a rise in the prevalence rate of spina bifida Japan. We determined first-trimester folate status Hokkaido women identified potential predictors. Participants were 15 266 pregnant Study on Environment Children's Health Cohort. Data extracted from self-reported questionnaires biochemical assay results. Demographic determinants low younger maternal age (adjusted OR (AOR) 1·48; 95 % CI 1·32, 1·66), lower educational level (AOR 1·27; 1·17, 1·39) annual income 1·11; 1·01, 1·22). Plasma cotinine concentrations 1·19-65·21 nmol/l increased risk 1·20; 1·10, 1·31) >65·21 further 1·91; 1·70, 2·14). most favourable predictor was use folic acid (FA) supplements 0·19; 0·17, 0·22). Certain socio-demographic factors influence among Japanese women. Modifiable negative positive predictors active passive tobacco smoking FA supplements. Avoiding both using could improve