Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway
作者： Xiao-hong Wang , Dian-zeng Jia , Yong-ju Liang , Su-li Yan , Yan Ding
DOI: 10.1016/J.CANLET.2006.09.008
关键词:
摘要: Pyrazolon derivatives were reported to have cytotoxicity some tumour cells. In the present study, we investigated effect of Lgf-YL-9 on and cell apoptosis in human epidermoid carcinoma drug-sensitive parental KB cells multidrug resistant (MDR) KBv200 exhibited potent not only but also cells, IC(50) 3.81 3.45 microg/mL respectively. Importantly, effectively inhibited growth xenografts nude mice. Lgf-YL-9-induced was confirmed by chromatin condensation, DNA fragmentation, Annexin-V propidium iodide (PI) double-staining assay poly(ADP-ribose) polymerase (PARP) cleavage. Furthermore, Lgf-YL-9-mediated accompanied loss mitochondrial membrane potential (DeltaPsi(m)), release cytochrome c, activation caspases-3, -7, -9, intercalating DNA. Although associated with decrease DeltaPsi(m), reactive oxygen species (ROS) reduction interestingly observed both lines. The data suggest that has similar MDR is involved a new ROS-independent dysfunction pathway,
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sci-hub.se 参考文章(35)
L.W Fu, Y.M Zhang, Y.J Liang, X.P Yang, Q.C Pan, The multidrug resistance of tumour cells was reversed by tetrandrine in vitro and in xenografts derived from human breast adenocarcinoma MCF-7/adr cells European Journal of Cancer. ,vol. 38, pp. 418- 426 ,(2002) , 10.1016/S0959-8049(01)00356-2
H LIN, Y LEE, B CHEN, M TSAI, J LU, C CHOU, G JOW, Involvement of Bcl-2 family, cytochrome c and caspase 3 in induction of apoptosis by beauvericin in human non-small cell lung cancer cells. Cancer Letters. ,vol. 230, pp. 248- 259 ,(2005) , 10.1016/J.CANLET.2004.12.044
Tsutomu Arimura, Akiko Kojima-Yuasa, David Opare Kennedy, Isao Matsui-Yuasa, Reactive oxygen species-independent G1 arrest induced by evening primrose extract in Ehrlich ascites tumor cells Cancer Letters. ,vol. 207, pp. 19- 25 ,(2004) , 10.1016/J.CANLET.2003.11.001
Hajime Edatsugi, Takao Yamori, Akio Matsunaga, Kanami Yamazaki, Shigeo Sato, Yuki Nakajima, Kazuhiro Ishizu, Akiko Komi, Takashi Tsuruo, Osamu Nakanishi, Hiroshi Kohno, Kimiko Takezawa, Izumi Mita, Yasuhiro Matsuba, Toshio Andoh, Hironori Komatsu, Potent Antitumor Activity of MS-247, a Novel DNA Minor Groove Binder, Evaluated by an in Vitro and in Vivo Human Cancer Cell Line Panel Cancer Research. ,vol. 59, pp. 4042- 4049 ,(1999)
Adnan A. Bekhit, Hayam M. A. Ashour, Aida A. Guemei, Novel pyrazole derivatives as potential promising anti-inflammatory antimicrobial agents. Archiv Der Pharmazie. ,vol. 338, pp. 167- 174 ,(2005) , 10.1002/ARDP.200400940
Hyunsil Han, Alexander Stessin, Julia Roberts, Kenneth Hess, Narinder Gautam, Margarita Kamenetsky, Olivia Lou, Edward Hyde, Noah Nathan, William A. Muller, Jochen Buck, Lonny R. Levin, Carl Nathan, Calcium-sensing soluble adenylyl cyclase mediates TNF signal transduction in human neutrophils Journal of Experimental Medicine. ,vol. 202, pp. 353- 361 ,(2005) , 10.1084/JEM.20050778
Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Earl R. Kern, Paul F. Torrence, A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity. Bioorganic & Medicinal Chemistry Letters. ,vol. 16, pp. 3224- 3228 ,(2006) , 10.1016/J.BMCL.2006.03.043
Hitoshi Ohki, Kenji Hirotani, Hiroyuki Naito, Satoru Ohsuki, Megumi Minami, Akio Ejima, Yukiko Koiso, Yuichi Hashimoto, Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity. Bioorganic & Medicinal Chemistry Letters. ,vol. 12, pp. 3191- 3193 ,(2002) , 10.1016/S0960-894X(02)00568-1
Weimin Fan, Zhi-Ai Deng, Qi-Chao Pan, Li-Wu Fu, Screening and discovery of novel MDR modifiers from naturally occurring bisbenzylisoquinoline alkaloids. Anticancer Research. ,vol. 21, pp. 2273- 2280 ,(2001)
Patrick R Cammarata, James M Flynn, Estradiol attenuates mitochondrial depolarization in polyol-stressed lens epithelial cells. Molecular Vision. ,vol. 12, pp. 271- 282 ,(2006)