Synthesis of a platinum(II) complex with 2-(4-methoxy-phenyl) imidazo [4,5-f]-[1,10] phenanthrolin and study of its antitumor activity
作者： Qi-Pin Qin , Zhen-Feng Chen , Wen-Ying Shen , Yan-Hua Jiang , Dong Cao
DOI: 10.1016/J.EJMECH.2014.10.019
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摘要: Abstract A new platinum(II) complex of [PtII(L) (pn)]Cl·2H2O (1) (pn = 1,3-propanediamine) with 2-(4-methoxy-phenyl)imidazo [4,5-f]-[1,10]phenanthrolin (H-L) was synthesized and characterized. In 1, the platinum adopts a four-coordinated square planar geometry. Complex 1 exhibited selective cytotoxicity against NCI–H460, BEL-7402, SK-OV-3, SK-OV-3/DDP HeLa cell lines IC50 values in micromolar range (9.7–35.8 μM), but low toward normal human liver HL-7702 cells. caused cycle arrest at S phase it induced apoptosis by activation caspase-3/9. Various experiments showed that preferred to bind G-quadruplex c-myc. Taken together, we found exerted its antitumor activity mainly via inhibiting telomerase interaction c-myc quadruplex
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