Bone mineral density and risk of fractures in aging, obese post-menopausal women with type 2 diabetes. The GIUMO Study.

摘要: Background and aims: Type 2 diabetes mellitus (DM) has a high prevalence in aging obese postmenopausal women. It is not clear whether or produces an increase bone mineral density fracture rates. Objective: The main objective of this study was to investigate type DM higher vertebral, hip non-vertebral fractures Caucasian A secondary the influence quantitative ultrasound measurements heel (QUS) (BMD) measured by dual X-ray absorptiometry (DXA), both lumbar spine (L2–L4) proximal femur. Method: This prospective cohort 111 patients with 91 control individuals (CTR) over age 65 obese, recruited from 16 centers Spain. Main Outcome Measures: Lateral dorsal X-rays were performed assess vertebral fractures. Hip noted medical records, written reports studies. QUS made calcaneus BMD Results: Patients had than controls (0.979 g/cm2 vs 0.927 g/cm2, p=0.035), but we found no statistically significant differences showed similar values groups: BUA (69.3 dB/Mhz 66.7 dB/Mhz, p=0.291), SOS (1537 m/sg 1532 m/sg, p=0.249) QUI (87.5 83.7, p=0.153). No any case. There association between DM. crude odds ratio, without adjusting 1.045 (CI 957o 0.531; 2.059), adjusted ratio 95% 0.461; 1.863). Conclusions: In women, changes femur heel. did