Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma.
作者： Mitsutoshi Nakada , Daisuke Kita , Kazuya Futami , Junkoh Yamashita , Noboru Fujimoto
DOI: 10.3171/JNS.2001.94.3.0464
关键词:
摘要: Object. Acquisition of invasive and metastatic potentials through proteinase expression is an essential event in tumor progression. Among proteinases, matrix metalloproteinases (MMPs) are thought to play a key role progression the degradation extracellular matrix. In present study, authors examined MMP-2 (gelatinase A) membrane type 1 MMP (MT1-MMP), activator zymogen MMP-2, proMMP-2, together with tissue inhibitors (TIMP-1 TIMP-2) invasion astrocytic tumors humans. Methods. Analyses performed using sandwich enzyme immunoassays demonstrated that production levels proMMP-2 TIMP-1, but not TIMP-2, significantly higher glioblastomas multiforme than other grades tumors. Quantitative reverse transcription-polymerase chain reaction indicated MT1-MMP expressed predominantly glioblastoma tissues, its enhanced as grade increas...
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sci-hub.se 参考文章(42)
U P Thorgeirsson, D F Alonso, D E Gomez, H Yoshiji, Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. European Journal of Cell Biology. ,vol. 74, pp. 111- 122 ,(1997)
Taketoshi Shimada, Hiroyuki Nakamura, Kaname Yamashita, Ryo Kawata, Yasushi Murakami, Noboru Fujimoto, Hiroshi Sato, Motoharu Seiki, Yasunori Okada, Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasis. Clinical & Experimental Metastasis. ,vol. 18, pp. 179- 188 ,(2000) , 10.1023/A:1006749501682
Hiroyuki Nakamura, Masakuni Noguchi, Motoharu Seiki, Hirohisa Ueno, Kaname Yamashita, Yasunori Okada, Taketoshi Shimada, Noboru Fujimoto, Hiroshi Sato, Etsuhide Yamamoto, Enhanced Production and Activation of Progelatinase A Mediated by Membrane-Type 1 Matrix Metalloproteinase in Human Papillary Thyroid Carcinomas Cancer Research. ,vol. 59, pp. 467- 473 ,(1999)
Yasunori OKADA, Tatsuhisa MORODOMI, Jan J. ENGHILD, Ko SUZUKI, Atsushi YASUI, Isao NAKANISHI, Guy SALVESEN, Hideaki NAGASE, MATRIX METALLOPROTEINASE 2 FROM HUMAN RHEUMATOID SYNOVIAL FIBROBLASTS : PURIFICATION AND ACTIVATION OF THE PRECURSOR AND ENZYMIC PROPERTIES FEBS Journal. ,vol. 194, pp. 721- 730 ,(1990) , 10.1111/J.1432-1033.1990.TB19462.X
Lance A. Liotta, Garth L. Nicolson, Raymond Sawaya, Gregory N. Fuller, Ziya L. Gokaslan, Hiroshi Sato, Motoharu Seiki, Jasti S. Rao, Sanjeeva Mohanam, Masaaki Yamamoto, Differential Expression of Membrane-Type Matrix Metalloproteinase and Its Correlation with Gelatinase A Activation in Human Malignant Brain Tumors in Vivo and in Vitro Cancer Research. ,vol. 56, pp. 384- 392 ,(1996)
Takahisa Takino, Toshifumi Akizawa, Motoharu Seiki, Michiyasu Itoh, Hiroshi Sato, Takeshi Kinoshita, Processing of a Precursor of 72-Kilodalton Type IV Collagenase/Gelatinase A by a Recombinant Membrane-Type 1 Matrix Metalloproteinase Cancer Research. ,vol. 56, pp. 2535- 2538 ,(1996)
Zarin Kachra, Edith Beaulieu, Louis Delbecchi, Nathalie Mousseau, France Berthelet, Robert Moumdjian, Rolando Del Maestro, Richard Béliveau, Expression of matrix metalloproteinases and their inhibitors in human brain tumors. Clinical & Experimental Metastasis. ,vol. 17, pp. 555- 566 ,(1999) , 10.1023/A:1006760632766
P. Kleihues, P. C. Burger, B. W. Scheithauer, Definitions and Explanatory Notes Springer, Berlin, Heidelberg. pp. 11- 51 ,(1993) , 10.1007/978-3-642-84988-6_3
H Sato, M Kita, M Seiki, v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines. Journal of Biological Chemistry. ,vol. 268, pp. 23460- 23468 ,(1993) , 10.1016/S0021-9258(19)49485-4
Gangyong Li, Hyeong Reh Choi Kim, Rafael Fridman, Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells. Cancer Research. ,vol. 59, pp. 6267- 6275 ,(1999)