摘要: Inoculation of mice with most neurotropic strains the coronavirus mouse hepatitis virus results in an immune response-mediated demyelinating disease that serves as excellent animal model for human multiple sclerosis. Recent work has shown either virus-specific CD4(+) or CD8(+) T cells are able to mediate demyelination and also antibody response is crucial clearing infectious virus. Another exciting advance development recombinant coronaviruses, which, first time, will allow genetic manipulation entire viral genome.
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