Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors.

作者: C CARPENE , V ABELLO , Z IFFIUSOLTESZ , N MERCIER , B FEVE

DOI: 10.1016/J.PHRS.2008.04.005

关键词:

摘要: Inhibition of semicarbazide-sensitive amine oxidases (SSAO) and monoamine (MAO) reduces fat deposition in obese rodents: chronic administration the SSAO-inhibitor semicarbazide (S) combination with pargyline (MAO-inhibitor) has been shown to reduce body weight gain Zucker rats, while (E)-2-(4-fluorophenethyl)-3-fluoroallylamine, an SSAO- MAO-B inhibitor, reported limit diabetic mice. Our aim was state whether such limitation could occur non-obese, non-diabetic rats extend these observations other oxidase inhibitors. Prolonged treatment non-obese a high dose S (900 micromol kg(-1) day(-1)) reduced limited white adipose tissue enlargement. When chronically administered at threefold lower dose, also inhibited SSAO activity but not depot enlargement, suggesting that effects than inhibition were involved growth retardation. However, combined this SSAO, MAO, energy intake, deposition. Adipocytes from treated exhibited unchanged insulin responsiveness impaired antilipolytic responses substrates. Phenelzine clearly both MAO when tested on adipocytes. Obese receiving phenelzine i.p. 17 day(-1) for 3 weeks, blunted activities any tissue, diminished intra-abdominal tissue. Their adipocytes less responsive lipogenesis activation by tyramine or benzylamine. These suggest is sufficient impair limits adiposity as well rats.

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