Advances in the Evaluation of Respiratory Pathophysiology during Exercise in Chronic Lung Diseases.

摘要: Dyspnea and exercise limitation are among the most common symptoms experienced by patients with various chronic lung diseases linked to poor quality of life. Our understanding source nature perceived respiratory discomfort intolerance in has increased substantially recent years. These new mechanistic insights primary focus current review. Cardiopulmonary testing (CPET) provides a unique opportunity objectively evaluate ability system respond imposed incremental physiological stress. In addition measuring aerobic capacity quantifying an individual’s cardiac ventilatory reserves, we have expanded role CPET include evaluation symptom intensity, together simple “non-invasive” assessment relevant control parameters dynamic mechanics during standardized tests tolerance. This review explores application advances clinical pathophysiology obstructive pulmonary disease (COPD), asthma, interstitial (ILD) arterial hypertension (PAH)]. We hope demonstrate how this novel approach interpretation, which includes quantification activity-related dyspnea its underlying mechanisms, enhances our meaningfully intervene improve life these pathologically-distinct conditions.