Predictors of Mortality Poorly Predict Common Measures of Disease Progression in Idiopathic Pulmonary Fibrosis

摘要: Rationale: Mortality prediction is well studied in idiopathic pulmonary fibrosis (IPF), but little known about predictors of premortality disease progression. Identification patients at risk for progression would be useful clinical decision-making and designing trials.Objectives: To develop models IPF.Methods: In a large trial cohort with IPF (n = 1,113), we comprehensively screened multivariate candidate baseline past-change defined by 48-week worsening FVC, dyspnea (University California, San Diego Shortness Breath Questionnaire [UCSD SOBQ]), 6-minute-walk distance (6MWD), occurrence respiratory hospitalization, or death. Progression outcomes were modeled as appropriate, slope change using linear regression time to binary Cox proportional hazards models.Measurements Main Results: The overall experienced considerable...