Structure and function of mammalian ribosomes: II. Exchange of ribosomal subunits at various stages of in vitro polypeptide synthesis
作者： A.K. Falvey , T. Staehelin
DOI: 10.1016/0022-2836(70)90043-4
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摘要: Abstract 1. (1) During in vitro polypeptide chain termination by rat or mouse liver polysomes, 80 s monosomes briefly dissociate into free subunits, presumably at the moment of their relase from messenger. The subunits reassociate to form couples. In this reassociation step labeled 40 added incubation mixture freely compete with unlabeled subunits. 2. (2) ribosomes reformed after slowly exchange radioactive reaction mixture. equilibrium between and couples strongly favors latter. 3. (3) contrast termination, initiation polyphenylalanine synthesis directed polyuridylic acid, attach messenger without a dissociation step.
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