Applications of metabolomics in drug discovery and development.
作者： David S Wishart
DOI: 10.2165/00126839-200809050-00002
关键词:
摘要: … (a) chemometric approaches to metabolomics and (b) quantitative metabolomics. In chemometric … aimed at assessing ciclosporin and tacrolimus toxicity have shown increased levels of …
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Dennis A Smith, Esther F Schmid, Drug withdrawals and the lessons within. Current Opinion in Drug Discovery & Development. ,vol. 9, pp. 38- 46 ,(2006)
David S Wishart, Improving early drug discovery through ADME modelling: an overview. Drugs in R & D. ,vol. 8, pp. 349- 362 ,(2007) , 10.2165/00126839-200708060-00003
David S Wishart, Drug-target discovery in silico: using the web to identify novel molecular targets for drug action. SEB experimental biology series. ,vol. 58, pp. 145- ,(2007)
J. K. Nicholson, Ian D. Wilson, High resolution nuclear magnetic resonance spectroscopy of biological samples as an aid to drug development Progress in drug research. ,vol. 31, pp. 427- 479 ,(1987) , 10.1007/978-3-0348-9289-6_13
Bruce S. Kristal, Yevgeniya I. Shurubor, Rima Kaddurah-Daouk, Wayne R. Matson, High-Performance Liquid Chromatography Separations Coupled With Coulometric Electrode Array Detectors Methods of Molecular Biology. ,vol. 358, pp. 159- 174 ,(2007) , 10.1007/978-1-59745-244-1_10
Norbert W. Tietz, Clinical guide to laboratory tests ,(1983)
Xianlin Han, David M. Holtzman, Daniel W. McKeel, John Kelley, John C. Morris, Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis Journal of Neurochemistry. ,vol. 82, pp. 809- 818 ,(2002) , 10.1046/J.1471-4159.2002.00997.X
John C. Lindon, Elaine Holmes, Jeremy K. Nicholson, Metabonomics in pharmaceutical R&D. FEBS Journal. ,vol. 274, pp. 1140- 1151 ,(2007) , 10.1111/J.1742-4658.2007.05673.X
Sharmila Anishetty, Mrudula Pulimi, Gautam Pennathur, Brief communication: Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis Computational Biology and Chemistry. ,vol. 29, pp. 368- 378 ,(2005) , 10.1016/J.COMPBIOLCHEM.2005.07.001
Jeremy K. Nicholson, John Connelly, John C. Lindon, Elaine Holmes, Metabonomics: a platform for studying drug toxicity and gene function Nature Reviews Drug Discovery. ,vol. 1, pp. 153- 161 ,(2002) , 10.1038/NRD728