Conformational states of the kinase Lck regulate clustering in early T cell signaling
作者： Jérémie Rossy , Dylan M Owen , David J Williamson , Zhengmin Yang , Katharina Gaus
DOI: 10.1038/NI.2488
关键词:
摘要: Phosphorylation of the T cell antigen receptor (TCR) by the tyrosine kinase Lck is an essential step in the activation of T cells. Because Lck is constitutively active, spatial organization …
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researchgate.net 参考文章(50)
Nelson K. Y. Wong, Jacqueline C. Y. Lai, Darlene Birkenhead, Andrey S. Shaw, Pauline Johnson, CD45 Down-Regulates Lck-Mediated CD44 Signaling and Modulates Actin Rearrangement in T Cells Journal of Immunology. ,vol. 181, pp. 7033- 7043 ,(2008) , 10.4049/JIMMUNOL.181.10.7033
Wolfgang Paster, Christian Paar, Paul Eckerstorfer, Andrea Jakober, Karel Drbal, Gerhard J. Schütz, Alois Sonnleitner, Hannes Stockinger, Genetically Encoded Förster Resonance Energy Transfer Sensors for the Conformation of the Src Family Kinase Lck Journal of Immunology. ,vol. 182, pp. 2160- 2167 ,(2009) , 10.4049/JIMMUNOL.0802639
Titus J Boggon, Michael J Eck, Structure and regulation of Src family kinases. Oncogene. ,vol. 23, pp. 7918- 7927 ,(2004) , 10.1038/SJ.ONC.1208081
Kay K. Lee-Fruman, Tassie L. Collins, Steven J. Burakoff, Role of the Lck Src Homology 2 and 3 Domains in Protein Tyrosine Phosphorylation Journal of Biological Chemistry. ,vol. 271, pp. 25003- 25010 ,(1996) , 10.1074/JBC.271.40.25003
W RODGERS, D FARRIS, S MISHRA, Merging complexes: properties of membrane raft assembly during lymphocyte signaling. Trends in Immunology. ,vol. 26, pp. 97- 103 ,(2005) , 10.1016/J.IT.2004.11.016
Hao Zhang, Shaun-Paul Cordoba, Omer Dushek, P Anton Van Der Merwe, Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 19323- 19328 ,(2011) , 10.1073/PNAS.1108052108
Rajat Varma, Gabriele Campi, Tadashi Yokosuka, Takashi Saito, Michael L. Dustin, T Cell Receptor-Proximal Signals Are Sustained in Peripheral Microclusters and Terminated in the Central Supramolecular Activation Cluster Immunity. ,vol. 25, pp. 117- 127 ,(2006) , 10.1016/J.IMMUNI.2006.04.010
Michael S. Kuhns, Mark M. Davis, The Safety on the TCR Trigger Cell. ,vol. 135, pp. 594- 596 ,(2008) , 10.1016/J.CELL.2008.10.033
Paolo Annibale, Stefano Vanni, Marco Scarselli, Ursula Rothlisberger, Aleksandra Radenovic, Quantitative Photo Activated Localization Microscopy: Unraveling the Effects of Photoblinking PLoS ONE. ,vol. 6, pp. e22678- ,(2011) , 10.1371/JOURNAL.PONE.0022678
Konstantina Nika, Cristiana Soldani, Mogjiborahman Salek, Wolfgang Paster, Adrian Gray, Ruth Etzensperger, Lars Fugger, Paolo Polzella, Vincenzo Cerundolo, Omer Dushek, Thomas Höfer, Antonella Viola, Oreste Acuto, Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity. ,vol. 32, pp. 766- 777 ,(2010) , 10.1016/J.IMMUNI.2010.05.011