Effect of meteorological variables on the incidence of hand, foot, and mouth disease in children: a time-series analysis in Guangzhou, China.

摘要: Over the last decade, major outbreaks of hand, foot, and mouth disease (HFMD) have been reported in Asian countries, resulting thousands deaths among children. However, less is known regarding effect meteorological variables on incidence HFMD This study aims at quantifying relationship between children Guangzhou, China. The association weekly cases aged <15 years Guangzhou from 2008 to 2011 were analyzed using generalized additive model (GAM) time-series method, after controlling for long-term trend seasonality, holiday effects, influenza period delayed effects. Temperature relative humidity with one week lag significantly associated infection We found that a 1°C increase temperature led an 1.86% (95% CI: 0.92, 2.81%) number 0–14 years age group. A percent may lead 1.42% 0.97, 1.87%) provides quantitative evidence was high average humidity. one-week delay effects consistent enterovirus incubation potential time onset children’s sickness parental awareness response.