Lactic acidosis during telbivudine treatment for HBV: A case report and literature review
作者： Jia-Lin Jin , Piao Hu , Jia-Hong Lu , Su-Shan Luo , Xiao-Yun Huang
关键词:
摘要: All oral nucleoside analogues against hepatitis B virus, with an exception of telbivudine, have been reported causing lactic acidosis (LA). Here we report the first case chronic developing severe refractory LA during telbivudine monotherapy. A 36-year-old man Chinese origin received antiviral treatment for B. After 11 mo therapy, he developed anorexia, nausea, and vomiting mild muscle weakness. The patient was found elevated serum creatine phosphokinase up to 3683 U/L (upper limit normal 170 U/L) marked LA. did not resolve immediately following discontinuation telbivudine. His condition began improve after hemodialysis 16 times usage glucocorticosteroid. fully recovered wk treatment. This is documented caused by Besides phosphokinase, blood lactate level should also be closely monitored in patients receiving
sci-hub.st 参考文章(10)
Vishal Patel, S Susan Hedayati, Lactic acidosis in an HIV-infected patient receiving highly active antiretroviral therapy. Nature Reviews Nephrology. ,vol. 2, pp. 109- 114 ,(2006) , 10.1038/NCPNEPH0102
P. Latzin, U. Frey, H.L. Roiha, D.N. Baldwin, N. Regamey, M.-P.F. Strippoli, M. Zwahlen, C.E. Kuehni, , Prospectively assessed incidence, severity, and determinants of respiratory symptoms in the first year of life. Pediatric Pulmonology. ,vol. 42, pp. 41- 50 ,(2007) , 10.1002/PPUL.20542
Robert J. Fontana, Side effects of long-term oral antiviral therapy for hepatitis B. Hepatology. ,vol. 49, ,(2009) , 10.1002/HEP.22885
Mark Nelson, Alex Azwa, Ahmed Sokwala, Reena Shah Harania, Justin Stebbing, Fanconi syndrome and lactic acidosis associated with stavudine and lamivudine therapy. AIDS. ,vol. 22, pp. 1374- 1376 ,(2008) , 10.1097/QAD.0B013E328303BE50
M Osler, D Stead, K Rebe, G Meintjes, A Boulle, Risk factors for and clinical characteristics of severe hyperlactataemia in patients receiving antiretroviral therapy: a case-control study. Hiv Medicine. ,vol. 11, pp. 121- 129 ,(2010) , 10.1111/J.1468-1293.2009.00754.X
Stanley Martin Cohen, Ronald M. Levy, John F. Jovanovich, Joseph Ahn, Fatal Lactic Acidosis Associated With the Use of Combination Oral Medications to Treat Reactivation of Hepatitis B Journal of Clinical Gastroenterology. ,vol. 43, pp. 1008- 1010 ,(2009) , 10.1097/MCG.0B013E31819C3945
Alfredo Marzano, Andrea Marengo, Milena Marietti, Mario Rizzetto, Lactic acidosis during Entecavir treatment in decompensated hepatitis B virus-related cirrhosis Digestive and Liver Disease. ,vol. 43, pp. 1027- 1028 ,(2011) , 10.1016/J.DLD.2011.06.013
H. L.Y. Chan, Y. C. Chen, E. J. Gane, S. K. Sarin, D. J. Suh, T. Piratvisuth, B. Prabhakar, S. G. Hwang, G. Choudhuri, R. Safadi, T. Tanwandee, A. Chutaputti, C. Yurdaydin, W. Bao, C. Avila, A. Trylesinski, Randomized clinical trial: efficacy and safety of telbivudine and lamivudine in treatment-naïve patients with HBV-related decompensated cirrhosis. Journal of Viral Hepatitis. ,vol. 19, pp. 732- 743 ,(2012) , 10.1111/J.1365-2893.2012.01600.X
Hadewych J M Ter Hofstede, Siem De Marie, Norbert A Foudraine, Sven A Danner, Kees Brinkman, Clinical features and risk factors of lactic acidosis following long-term antiretroviral therapy: 4 fatal cases. International Journal of Std & Aids. ,vol. 11, pp. 611- 616 ,(2000) , 10.1258/0956462001916498
Robin McKenzie, Michael W. Fried, Richard Sallie, Hari Conjeevaram, Adrian M. Di Bisceglie, Yoon Park, Barbara Savarese, David Kleiner, Maria Tsokos, Carlos Luciano, Timothy Pruett, Jennifer L. Stotka, Stephen E. Straus, Jay H. Hoofnagle, Hepatic failure and lactic acidosis due to fialuridine (fiau), an investigational nucleoside analogue for chronic hepatitis b The New England Journal of Medicine. ,vol. 333, pp. 1099- 1105 ,(1995) , 10.1056/NEJM199510263331702