Lethal weapons: DAP-kinase, autophagy and cell death

作者: Shani Bialik , Adi Kimchi

DOI: 10.1016/J.CEB.2009.11.004

关键词:

摘要: Recently, DAP-kinase was identified as one of the essential regulators autophagy, activated by signals such cytokines and ER stress. is a tumor suppressor that mediates several cell death pathways, apoptosis programmed necrosis. Likewise, functional studies suggest may direct autophagy specifically towards autophagic death. Several recent have mapped function to distinct stages in signaling. These include Beclin-1/phosphatidylinositol 3-kinase (PI(3)K) complex, which necessary for autophagosome formation, an interaction with LC3 binding protein, MAP1B, regulate vesicle trafficking. This review will summarize mechanistic linked regulation general, death, particular.

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