Differential interactions between Beclin 1 and Bcl-2 family members.
作者： Shlomit Erlich , Liat Mizrachy , Oshik Segev , Liora Lindenboim , Ofir Zmira
DOI: 10.4161/AUTO.4713
关键词:
摘要: Autophagy, a cellular degradation system, promotes both cell death and survival. The interaction between Bcl-2 family proteins Beclin 1, interacting protein that autophagy, can mediate crosstalk autophagy apoptosis. We investigated the anti-and pro-apoptotic with 1. Our results show 1 directly interacts Bcl-2, Bcl-xL, Bcl-w to lesser extent Mcl-1. does not bind proteins. anti-apoptotic Bcl-xL was inhibited by BH3-only proteins, but multi-domain Sequence alignment structural modeling suggest contains putative BH3-like domain which may interact hydrophobic grove of Bcl-xL. Mutation amino acids predicted this association BH3 only proapoptotic modulate intera...
sci-hub.se 参考文章(32)
Devrim Gozuacik, Adi Kimchi, Autophagy and Cell Death Current Topics in Developmental Biology. ,vol. 78, pp. 217- 245 ,(2007) , 10.1016/S0070-2153(06)78006-1
Kristy Brown, Beth Levine, Xiao Huan Liang, Jie Yu, Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function Cancer Research. ,vol. 61, pp. 3443- 3449 ,(2001)
D. Sulzer, Kristin E. Larsen, Autophagy in neurons: a review. Histology and Histopathology. ,vol. 17, pp. 897- 908 ,(2002) , 10.14670/HH-17.897
Xiao Huan Liang, Linda K. Kleeman, Hui Hui Jiang, Gerald Gordon, James E. Goldman, Gail Berry, Brian Herman, Beth Levine, Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein Journal of Virology. ,vol. 72, pp. 8586- 8596 ,(1998) , 10.1128/JVI.72.11.8586-8596.1998
Xiao Huan Liang, Saadiya Jackson, Matthew Seaman, Kristy Brown, Bettina Kempkes, Hanina Hibshoosh, Beth Levine, None, Induction of autophagy and inhibition of tumorigenesis by beclin 1 Nature. ,vol. 402, pp. 672- 676 ,(1999) , 10.1038/45257
Liora Lindenboim, Junying Yuan, Reuven Stein, Bcl-xS and Bax induce different apoptotic pathways in PC12 cells Oncogene. ,vol. 19, pp. 1783- 1793 ,(2000) , 10.1038/SJ.ONC.1203495
J. M. Adams, The Bcl-2 Protein Family: Arbiters of Cell Survival Science. ,vol. 281, pp. 1322- 1326 ,(1998) , 10.1126/SCIENCE.281.5381.1322
Fulvio Reggiori, Daniel J Klionsky, Autophagosomes: biogenesis from scratch? Current Opinion in Cell Biology. ,vol. 17, pp. 415- 422 ,(2005) , 10.1016/J.CEB.2005.06.007
Sophie Pattingre, Amina Tassa, Xueping Qu, Rita Garuti, Xiao Huan Liang, Noboru Mizushima, Milton Packer, Michael D. Schneider, Beth Levine, Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy Cell. ,vol. 122, pp. 927- 939 ,(2005) , 10.1016/J.CELL.2005.07.002
Anthony Letai, Michael C. Bassik, Loren D. Walensky, Mia D. Sorcinelli, Solly Weiler, Stanley J. Korsmeyer, Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell. ,vol. 2, pp. 183- 192 ,(2002) , 10.1016/S1535-6108(02)00127-7