Theoretical research into anticancer activity of diterpenes isolated from the paraiban flora.
作者： Luciana Scotti , Hamilton Ishiki , Francisco JB Mendonça Junior , Paula F Santos , Josean F Tavares
DOI: 10.1177/1934578X1400900707
关键词:
摘要: Many studies of the scientific literature discuss anticancer activity diterpenes inhibiting Akt/IKK/NF-kappaB pro-survival signaling cascade, mainly by activation serine/threonine phosphatase PP2A. The aim this work was to evaluate and compare potential three atisane, kaurane trachylobane extracted from roots Xylopia langsdorffiana. Thus, we investigated reactivity (H-L(GAP) parameter), HOMO atmosphere favorable neutralize radical reactivity, docking compounds with With all approaches, theoretical study showed that atisane have characteristics for antitumor activity, like electron donating ability greater hydrophilic interactions enzyme, inhibition Akt/IKK/NF-kappaB,
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