Importance and regulation of the colonic mucus barrier in a mouse model of colitis
作者： J. Petersson , O. Schreiber , G. C. Hansson , S. J. Gendler , A. Velcich
关键词:
摘要: … In this study, we explored the role of the mucus layer and the mucins Muc1 and Muc2 in induction of colitis. Furthermore, we investigated in vivo whether the mucus secretion was …
elsevier.com
sci-hub.se 参考文章(28)
J.R. Gum, J.W. Hicks, N.W. Toribara, B. Siddiki, Y.S. Kim, Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. Journal of Biological Chemistry. ,vol. 269, pp. 2440- 2446 ,(1994) , 10.1016/S0021-9258(17)41965-X
Steffen Backert, Matthias Selbach, Role of type IV secretion in Helicobacter pylori pathogenesis Cellular Microbiology. ,vol. 10, pp. 1573- 1581 ,(2008) , 10.1111/J.1462-5822.2008.01156.X
Maria Van der Sluis, Barbara A.E. De Koning, Adrianus C.J.M. De Bruijn, Anna Velcich, Jules P.P. Meijerink, Johannes B. Van Goudoever, Hans A. Büller, Jan Dekker, Isabelle Van Seuningen, Ingrid B. Renes, Alexandra W.C. Einerhand, Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection Gastroenterology. ,vol. 131, pp. 117- 129 ,(2006) , 10.1053/J.GASTRO.2006.04.020
Malin E. V. Johansson, Jenny K. Gustafsson, Karolina E. Sjöberg, Joel Petersson, Lena Holm, Henrik Sjövall, Gunnar C. Hansson, Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLOS ONE. ,vol. 5, ,(2010) , 10.1371/JOURNAL.PONE.0012238
Fredrik Backhed, Ruth E Ley, Justin L Sonnenburg, Daniel A Peterson, Jeffrey I Gordon, Host-Bacterial Mutualism in the Human Intestine Science. ,vol. 307, pp. 1915- 1920 ,(2005) , 10.1126/SCIENCE.1104816
Kirk S. B. Bergstrom, Vanessa Kissoon-Singh, Deanna L. Gibson, Caixia Ma, Marinieve Montero, Ho Pan Sham, Natasha Ryz, Tina Huang, Anna Velcich, B. Brett Finlay, Kris Chadee, Bruce A. Vallance, Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa PLOS Pathogens. ,vol. 6, ,(2010) , 10.1371/JOURNAL.PPAT.1000902
R R Parmley, S J Gendler, Cystic fibrosis mice lacking Muc1 have reduced amounts of intestinal mucus. Journal of Clinical Investigation. ,vol. 102, pp. 1798- 1806 ,(1998) , 10.1172/JCI3820
Michael A McGuckin, Alison L Every, Caroline D Skene, Sara K Linden, Yok Teng Chionh, Agnieszka Swierczak, Julie McAuley, Stacey Harbour, Maria Kaparakis, Richard Ferrero, Philip Sutton, None, Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. Gastroenterology. ,vol. 133, pp. 1210- 1218 ,(2007) , 10.1053/J.GASTRO.2007.07.003
M. E. V. Johansson, M. Phillipson, J. Petersson, A. Velcich, L. Holm, G. C. Hansson, The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 15064- 15069 ,(2008) , 10.1073/PNAS.0803124105
Dae Ahn, Suzanne Crawley, Ryota Hokari, Shingo Kato, Stacey Yang, Jian Li, Young Kim, TNF-alpha Activates MUC2 Transcription via NF-kappaB but Inhibits via JNK Activation Cellular Physiology and Biochemistry. ,vol. 15, pp. 29- 40 ,(2005) , 10.1159/000083636