The Drosophila saxophone gene: a serine-threonine kinase receptor of the TGF-beta superfamily
作者： T Xie , A. Finelli , R. Padgett
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摘要: The Drosophila decapentaplegic (dpp) gene encodes a transforming growth factor-beta (TGF-beta)-like protein that plays key role in several aspects of development. Transduction the DPP signal was investigated by cloning serine-threonine kinase transmembrane receptors from because this type receptor is specific for TGF-beta-like ligands. Here evidence provided demonstrating saxophone (sax) gene, previously identified female sterile locus, I receptor. Embryos sax mothers and dpp embryos exhibit similar mutant phenotypes during early gastrulation, these two loci genetic interactions, which suggest they are utilized same pathway. These data dpp.
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