Genetic determinants of aggressive breast cancer.

摘要: The development and spread of breast other human cancers are caused by the overexpression, mutation, and/or deletion specific genes that drive these events. Finding genetic molecular differences between cancerous healthy cells can reveal determinants cancer. This knowledge results in a better understanding carcinogenic process improved predictive power, with implications for identifying new drug targets, designing novel therapies, improving preclinical clinical studies. We review concepts biomarker, marker, determinant cancer, particular focus on most aggressive lethal form termed inflammatory cancer (IBC). Using IBC as an example, we describe detail approaches to identify responsible for—and not merely associated with—this disease.