Beyond immune checkpoint blockade: emerging immunological strategies.
作者： Daniel V. Araujo , Tak W. Mak , Tak W. Mak , Tak W. Mak , Thorsten Berger
DOI: 10.1038/S41573-021-00155-Y
关键词:
摘要: The success of checkpoint inhibitors has accelerated the clinical implementation of a vast mosaic of single agents and combination immunotherapies. However, the lack of clinical translation for a number of immunotherapies as monotherapies or in combination with checkpoint inhibitors has clarified that new strategies must be employed to advance the field. The next chapter of immunotherapy should examine the immuno-oncology therapeutic failures, and consider the complexity of immune cell–cancer cell interactions to better design …
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Chris Fellner, Ipilimumab (yervoy) prolongs survival in advanced melanoma: serious side effects and a hefty price tag may limit its use. P & T : a peer-reviewed journal for formulary management. ,vol. 37, pp. 503- 530 ,(2012)
Amit A. Lugade, James P. Moran, Scott A. Gerber, Robert C. Rose, John G. Frelinger, Edith M. Lord, Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor Journal of Immunology. ,vol. 174, pp. 7516- 7523 ,(2005) , 10.4049/JIMMUNOL.174.12.7516
Simona Negrini, Vassilis G. Gorgoulis, Thanos D. Halazonetis, Genomic instability — an evolving hallmark of cancer Nature Reviews Molecular Cell Biology. ,vol. 11, pp. 220- 228 ,(2010) , 10.1038/NRM2858
Napoleone Ferrara, Kenneth J Hillan, Hans-Peter Gerber, William Novotny, None, Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer Nature Reviews Drug Discovery. ,vol. 3, pp. 391- 400 ,(2004) , 10.1038/NRD1381
Reinhard E. Voll, Martin Herrmann, Edith A. Roth, Christian Stach, Joachim R. Kalden, Irute Girkontaite, Immunosuppressive effects of apoptotic cells Nature. ,vol. 390, pp. 350- 351 ,(1997) , 10.1038/37022
Bond Almand, Joseph I. Clark, Ekaterina Nikitina, James van Beynen, Nicholas R. English, Stella C. Knight, David P. Carbone, Dmitry I. Gabrilovich, Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. Journal of Immunology. ,vol. 166, pp. 678- 689 ,(2001) , 10.4049/JIMMUNOL.166.1.678
T Shimizu, F Hirata, S Nomiyama, O Hayaishi, Indoleamine 2,3-dioxygenase. Purification and some properties. Journal of Biological Chemistry. ,vol. 253, pp. 4700- 4706 ,(1978) , 10.1016/S0021-9258(17)30447-7
Adrienne H Long, Waleed M Haso, Jack F Shern, Kelsey M Wanhainen, Meera Murgai, Maria Ingaramo, Jillian P Smith, Alec J Walker, M Eric Kohler, Vikas R Venkateshwara, Rosandra N Kaplan, George H Patterson, Terry J Fry, Rimas J Orentas, Crystal L Mackall, 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors Nature Medicine. ,vol. 21, pp. 581- 590 ,(2015) , 10.1038/NM.3838
Vijay Shankaran, Hiroaki Ikeda, Allen T. Bruce, J. Michael White, Paul E. Swanson, Lloyd J. Old, Robert D. Schreiber, IFNγ, and lymphocytes prevent primary tumour development and shape tumour immunogenicity Nature. ,vol. 410, pp. 1107- 1111 ,(2001) , 10.1038/35074122
Nicholas Butowski, Howard Colman, John F. De Groot, Antonio M. Omuro, Lakshmi Nayak, Patrick Y. Wen, Timothy F. Cloughesy, Adhirai Marimuthu, Sam Haidar, Arie Perry, Jason Huse, Joanna Phillips, Brian L. West, Keith B. Nolop, Henry H. Hsu, Keith L. Ligon, Annette M. Molinaro, Michael Prados, Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study Neuro-oncology. ,vol. 18, pp. 557- 564 ,(2016) , 10.1093/NEUONC/NOV245