Hyperosmotic blood-brain barrier disruption in brains of rats with an intracerebrally transplanted RG-C6 tumor.

摘要: To test the results of blood-brain barrier (BBB) disruption in treatment brain tumor, RG-C6 glioma was transplanted into brains rats. Intracarotid infusions normal saline and hyperosmotic mannitol were then made, followed by intravenous injection Evans blue dye plus albumin (EB, MW 68,000), horseradish peroxidase (HRP, 40,000), 5-fluorouracil (5-FU, 130). Uptake drug consistency levels tumor varied widely among these three agents. Both EB HRP penetrated tumors but did not stain tissues. After BBB opening, penetration drastically increased; however, uptake increased. The concentration 5-FU higher than that serum and, although it increased 1.5-fold after increase statistically significant. Conversely, there a progressive concentrations tumor-free regions (p less 0.05). These observations suggest an intracarotid infusion may neurotoxicity because allows greater delivery anticancer drugs tissue