Relationship of Hippocampal Volumes and Posttraumatic Stress Disorder Symptoms Over Early Posttrauma Periods

作者: Hong Xie , Meredith Claycomb Erwin , Jon D. Elhai , John T. Wall , Marijo B. Tamburrino

DOI: 10.1016/J.BPSC.2017.11.010

关键词:

摘要: Abstract Background Smaller hippocampal volume is associated with more severe posttraumatic stress disorder (PTSD) symptoms years after traumatic experiences. Posttraumatic appear early following trauma, but the relationship between and PTSD symptom severity during posttrauma periods not well understood. It possible that inverse already present soon trauma. To test this possibility, we prospectively examined association volumes of within weeks to months trauma due a motor vehicle collision. Methods Structural magnetic resonance imaging scans 44 survivors were collected about 2 again at 3 collision measure volumes. The Checklist was used evaluate each scan time. Full ( n = 5) or partial 6) evaluated using Clinician-Administered Scale months. Results Left both time points negatively correlated scores, subscores for re-experiencing also hyperarousal Finally, neither left nor right significantly changed posttrauma. Conclusions results suggest small increased risk development. Furthermore, did arise from shifts in

参考文章(52)
Nadia Quijije, Updates in the neuroendocrinology of stress and its clinical management. Current Opinion in Endocrinology, Diabetes and Obesity. ,vol. 22, pp. 319- 324 ,(2015) , 10.1097/MED.0000000000000176
Ronald C. Kessler, Posttraumatic stress disorder: the burden to the individual and to society. The Journal of Clinical Psychiatry. ,vol. 61, pp. 4- 12 ,(2000)
Israel Liberzon, Chandra Sekhar Sripada, The functional neuroanatomy of PTSD: a critical review Progress in Brain Research. ,vol. 167, pp. 151- 169 ,(2007) , 10.1016/S0079-6123(07)67011-3
A Sekiguchi, M Sugiura, Y Taki, Y Kotozaki, R Nouchi, H Takeuchi, T Araki, S Hanawa, S Nakagawa, C M Miyauchi, A Sakuma, R Kawashima, Brain structural changes as vulnerability factors and acquired signs of post-earthquake stress. Molecular Psychiatry. ,vol. 18, pp. 618- 623 ,(2013) , 10.1038/MP.2012.51
Linda Chao, Michael Weiner, Thomas Neylan, Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder. Psychiatry Research-neuroimaging. ,vol. 213, pp. 193- 201 ,(2013) , 10.1016/J.PSCYCHRESNS.2013.03.002
Meena Vythilingam, David A. Luckenbaugh, Thomas Lam, Charles A. Morgan, Deborah Lipschitz, Dennis S. Charney, J. Douglas Bremner, Steven M. Southwick, Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder Psychiatry Research-neuroimaging. ,vol. 139, pp. 89- 99 ,(2005) , 10.1016/J.PSCYCHRESNS.2005.04.003
Chadi G Abdallah, Ramiro Salas, Andrea Jackowski, Philip Baldwin, João R Sato, Sanjay J Mathew, None, Hippocampal volume and the rapid antidepressant effect of ketamine. Journal of Psychopharmacology. ,vol. 29, pp. 591- 595 ,(2015) , 10.1177/0269881114544776
Ramón J.L. Lindauer, Miranda Olff, Els P.M. van Meijel, Ingrid V.E. Carlier, Berthold P.R. Gersons, Cortisol, Learning, Memory, and Attention in Relation to Smaller Hippocampal Volume in Police Officers with Posttraumatic Stress Disorder Biological Psychiatry. ,vol. 59, pp. 171- 177 ,(2006) , 10.1016/J.BIOPSYCH.2005.06.033
Ulrike Schmidt, Sebastian F. Kaltwasser, Carsten T. Wotjak, Biomarkers in Posttraumatic Stress Disorder: Overview and Implications for Future Research Disease Markers. ,vol. 35, pp. 43- 54 ,(2013) , 10.1155/2013/835876