A comparison of urinary nuclear matrix protein-22 and bladder tumour antigen tests with voided urinary cytology in detecting and following bladder cancer:the prognostic value of false-positive results

摘要: Objectives To evaluate the diagnostic and prognostic value of nuclear matrix protein-22 (NMP22) bladder tumour antigen (BTAstat) tests compared with voided urinary cytology (VUC) in detecting following cancer, assessing particularly false-positive test results patients followed up for cancer. Patients methods From 739 suspected having urine samples NMP22 BTAstat tests, VUC analysis, were collected before cystoscopy. All underwent transurethral resection lesions or mapping, a mean (range) 27.3 (3–65) months. Results In 406 overall sensitivity was 85% NMP22, 70% 62% VUC. For histological grades 1–3 transitional cell carcinoma 82%, 89% 94% 53%, 76% 90% BTAstat, 38%, 68% VUC, respectively. Although invasive > 85% all statistically more sensitive than superficial tumours. The optimal threshold calculated using receiver operating characteristics curve, 8.25 U/mL. specificity 67% 96% remained > 87% independent benign findings. contrast, no apparent genitourinary disease on histology, had significantly higher (94% 92%, respectively; P = 0.003) group chronic cystitis (52% both tests). Forty cancer at biopsy recurrence after follow-up 7.7 (3–15) months; previous history cancer. According to subsequent recurrence, positive negative predictive values 18% 91% 13% 88% 79% Both predicted (log-rank test, P < 0.001 P = 0.004, respectively), but produced similar correlation (P = 0.778). Conclusion are better low-grade they have lower specificity. After excluding diseases potential interfere these is increased considerably. False-positive from not correlate future recurrences.