A Multicenter Trial Evaluation of the Fibrin/Fibrinogen Degradation Products Test for Detection and Monitoring of Bladder Cancer

作者: B.S. Schmetter , K.K. Habicht , D.L. Lamm , A. Morales , N.H. Bander

DOI: 10.1016/S0022-5347(01)64321-0

关键词:

摘要: AbstractPurpose: Presently there is a lack of effective, noninvasive tests for the detection and monitoring bladder cancer. Measurement fibrin/fibrinogen degradation products in urine has been shown to be useful indicator carcinoma. The objective this study was evaluate AuraTek FDP rapid immunoassay device urinary associated with cancer.Materials Methods: A prospective multicenter conducted compare cytology hemoglobin dipstick cancer 192 patients history cancer.Results: significantly more sensitive (68%) than conventional (34%, p <0.001) or (41%, tumors, particularly low stage grade disease. In subjects invasive disease (T2-T4) test had sensitivity 100%. Specificity 96% ...

参考文章(20)
William L. Parry, George P. Hemstreet, Cancer detection by quantitative fluorescence image analysis. The Journal of Urology. ,vol. 139, pp. 270- 274 ,(1988) , 10.1016/S0022-5347(17)42384-6
E. J. Manseau, B. Berse, K. Tognazzi, L. F. Brown, H. F. Dvorak, R. W. Jackman, D. R. Senger, Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. American Journal of Pathology. ,vol. 143, pp. 1255- 1262 ,(1993)
Oliver Howard Beahrs, Max H. Myers, Manual for Staging of Cancer ,(1992)
Susan Fuggle, Roy Bicknell, David Cranston, Tim O'Brien, Adrian L. Harris, Different Angiogenic Pathways Characterize Superficial and Invasive Bladder Cancer Cancer Research. ,vol. 55, pp. 510- 513 ,(1995)
Carlos Cordon-Cardo, Yves Fradet, William Fair, Myron R. Melamed, David D. Wartinger, Immunopathologic analysis of human urinary bladder cancer. Characterization of two new antigens associated with low-grade superficial bladder tumors. American Journal of Pathology. ,vol. 140, pp. 375- 385 ,(1992)
Martin V. Haspel, Donald L. Lamm, Eric Thompson, Richard P. McCabe, Kendall O. Smith, M. G. Hanna, Nicholas Pomato, A Diagnostic-Prognostic Test for Bladder Cancer Using a Monoclonal Antibody-based Enzyme-linked Immunoassay for Detection of Urinary Fibrin(ogen) Degradation Products Cancer Research. ,vol. 44, pp. 5886- 5893 ,(1984)
Janice A. Nagy, Lawrence F. Brown, Donald R. Senger, Naomi Lanir, Livingston Van De Water, Ann M. Dvorak, Harold F. Dvorak, Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochimica et Biophysica Acta. ,vol. 948, pp. 305- 326 ,(1989) , 10.1016/0304-419X(89)90004-8
Laurence F. Greene, STUDY OF FIVE HUNDRED PATIENTS WITH ASYMPTOMATIC MICROHEMATURIA Journal of the American Medical Association. ,vol. 161, pp. 610- 613 ,(1956) , 10.1001/JAMA.1956.02970070042011
Z. Wajsman, P.D. Williams, J. Greco, G.P. Murphy, Further study of fibrinogen degradation products in bladder cancer detection Urology. ,vol. 12, pp. 659- 661 ,(1978) , 10.1016/0090-4295(78)90427-2
M. F.* Sarosdy, R.W. deVere White, M.S. Soloway, J. Sheinfeld, M.A. Hudson, P.F. Schellhammer, M.V. Jarowenko, G. Adams, B.A. Blumenstein, Results of a Multicenter Trial using the BTA Test to Monitor for and Diagnose Recurrent Bladder Cancer The Journal of Urology. ,vol. 154, pp. 379- 384 ,(1995) , 10.1016/S0022-5347(01)67054-X