Effect of retention time on NMP22 bladder check assay results in voided urine

摘要: Background: Bladder cancer health care costs are high, primarily due to the need for long-term follow-up. Several markers have been developed detect presence of urothelial cell carcinoma (UCC) in urinary tract. These differing sensitivity and specificity. The nuclear matrix protein-22 (NMP22) test increases ability recurrent bladder cancer. Objectives: aim this study was evaluate possible changes results depending on length retention time collected urine. Patients Methods: Between January June 2006 we prospectively evaluated voided urine specimens 69 patients undergoing control cystoscopy or transurethral resection primary We tested NMP22 first morning sample samples after 5 min, 30 min 2 h bladder. Sensitivity, specificity, positive predictive value (PPV) negative (NPV) were determined, grouped according tumor stage grade. Results: Global similar all groups (first 5-min, 30-min 2-h retention); best observed at point (80%). Specificity varied from 75% 100% obtained h. PPV 95.5–100% different periods, while NPV range 27.3–33.3%. Conclusion: Although not a large series, it appears that there is tendency towards better with time. It necessary wait operability. ARTICLE INFO